Nrampl gene

Table 11.3 Selected microorganisms toward which innate resistance in the mouse is governed by the Nrampl gene.

Bellamy R, Ruwende C, Corrah T et al 1998 Variations in the NRAMPl gene and susceptibility to tuberculosis in West Africans. N Engl J Med 338 640—604 Bellamy R, Beyers N, McAdam KP et al 2000 Genetic susceptibihty to tuberculosis in Africans a genome-wide scan. Proc Nad Acad Sci USA 97 8005—8009 Casanova JL, Abel L 2002 Genetic dissection of immunity to mycobacteria the human model. Annu Rev Immunol 20 581—620... 

No data were provided on the identities of the host proteins altered following infection. The Nrampl gene determines cellular resistance to intracellular parasites in mice (Govoni et al., 1996). 

Research for infectious diseases also seeks to identify the critical steps of host defense to infection. One recent approach has been to isolate and characterize a mouse gene, Beg Nrampl), which controls natural susceptibility to infection with Mycobacteria, as well as Salmonella and Leishmania and test the alleles of the human homologue for linkage with tuberculosis and leprosy [6]. Understanding the mechanism of action will enable scientists to design better drugs to mimic the action of the resistant allele. 

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