NP-Based Gene Delivery

Gene delivery NPs can be formulated from diverse materials with unique architectures and loaded with DNA by condensation, encapsulation, surface attachment or entrapment. They offer multifold advantages over other methods of gene delivery  

NPs are relatively easier to make, less expensive and more stable during longterm storage. Furthermore, they can be tested for the absence of endotoxins and other harmful ingredients and, therefore, are safe to use. 

Because NPs can be synthesized chemically, free of animal-derived components, they are ideal for use when absence of animal-derived components is a priority, for example, in biopharmaceutical applications. Absence of animal-derived components may also facilitate regulatory compliance. 

The absence of lipids in non-lipid-based NPs makes them suitable in lipid or signal transduction research. 

In the field of transgenesis, NP-mediated gene delivery might be useful in species for which conventional methods of gene delivery are not effective (e.g. chicken). 

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NP-Based Gene Delivery for Stem Cell Isolation and Culture... 

NP-Based Gene Delivery for Inducing Differentiation of Stem Cells... 

NP-Based Gene Delivery into Sperm (nanoSMGT)... 

Although promising, NP-based gene delivery methods have not yet been applied to mammalian embryos. However, a few attempts have been made to use NP-based gene delivery methods in species in which conventional methods of gene... 

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