Noyes and Whitney equation

The kinetics of the dissolution process obeys the Noyes and Whitney equation [26], revised by Nernst and Brunner ... 

By simple manipulation, the rate of dissolution, the amount of dissolved solid per unit time, can be calculated by the Noyes and Whitney equation, written as... 

The dissolution rate of a drug substance is related to its aqueous solubility. For neutral drugs there is a direct correlation between the solubility and dissolution rate as demonstrated by the Noyes and Whitney equation (37.11). However, depending on the pH of the dissolution medium... 

Dissolution, precipitation, and crystallization that can occur during dissolution of an amorphous system are summarized in Fig. 15.4 (Alonzo et al. 2010). Modified Noyes and Whitney equation is used to describe the dissolution pathway, where dc/dl represents the dissolution rate which is directly proportional to the surface area (A) and the difference between the solution concentration (C) and the equilibrium concentration (Cgq Alonzo et al. 2010). In the nucleation path, J represents the nucleation rate, which is proportional to the degree of supersaturation (S). For the growth path, the rate of crystal growth is also proportional to the difference between the actual solution concentration and the equilibrium concentration (Alonzo et al. 2010). 

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See also in sourсe #XX -- [ ]

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