Novel nitrogen transformations

In next chapter, Khan and Ather review different aspects of the microbial transformations of the important nitrogenous molecules, as they have diverse biological activities. This chapter provides a critical update of the microbial transformations reported in recent years, targeting novel biocatalysts from microbes. 

A novel complex, Mo[N( Bu) (Ar)]3 140, was prepared and shown to activate the triple bond in molecular nitrogen in a stoichiometric fashion. However, the complex, when used for alkyne metathesis, does not affect the expected transformation, but undergoes a vigorous endothermic process in a CH2CI2 solution. The resultant solution... 

It is well known that nucleophiles such as ammonia and amines are able to open pyran-2-one rings. The resultant ring-opened products are often able to recyclize under acidic conditions to yield pyridone and benzene derivatives. This section is mainly concerned with ring-transformation reactions induced by nitrogen nucleophiles not previously discussed <1984CHEC>, as well as some novel chemistry involving nitrogen nucleophiles. 

A new ring transformation reaction of 4,5-dibenzoyl-l,2,3-triazoline (395) has been reported, which appears to involve nitrogen expulsion followed by a C—NH proton shift. This sequence opens a novel route to enamino diketones (396) and tetraacylpyrrolidines (and traces of aziridine 398) <76jhci 153). 

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