Norsertraline, dynamic kinetic

Thalen, L. K., Zhao, D. B., Sortais, J. B., Paetzold, J., et al. (2009). A chemoenzymatic approach to enantiomerically pure amines using dynamic kinetic resolution Application to the synthesis of norsertraline. Chem. Eur.., 15,3403-3410. 

This highly efficient DKR methodology was applied to the synthesis of the selective serotonin reuptake inhibitor, norsertraline (Scheme 1.4), which is used to treat depression. For the application of enzymatic dynamic kinetic resolution in stereoselective synthesis, see chapter 57. 

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