Norethynodrel

1 to 2 hours is filtered off, washed until neutral and dried In vacuo over calcium chloride at room temperature. 

In order to prepare the monoacetate, the crude diacetate Is suspended in 150 cc of methanol and, after adding 1.5 cc, concentrated hydrochloric acid, heated to boiling for 15 minutes in a nitrogen atmosphere. The crude monoacetate which separates upon the addition of water after cooling is filtered off, washed and dried in vacuo over calcium chloride at room temperature. The pure 17-acetate, obtained after repeated recrystallizations from methylene chloride/hexane has a MP of 161° to 162°C. 

Common Name 13-methyl-17-ethynyl-l7-hydroxy-1,2,3,4,6,7,8,9,11,12,13,14,16,17-tetra-decahydro-15H-cyclopenta(Q )phenanthreri-3-one 

Convenient starting materials are the ethers of 3-hydroxy-13-methyl-1,4,6,7,8,9,11,12,13,-14,16,17-dodecahydro-15H-oyclopenta Q )phenanthren-17-one described in U.S. Patent 2,655,518, according to U.S. Patent 2,691,028 where the following preparation is also described. The methyl ether is also designated as 3-methoxy-17-oxo-2,5-estradiene. 

To a refluxing solution of 10 parts of 3-methoxy-17-ethynyl-17-hydroxy-13-methyl-1,4,6,7,- 

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Norethisterone (see also Progestins Combined oral contraceptives) Norethynodrel (see also Progestins Combined oral contraceptives... 

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