Norbomane-2-carboxylic acid

Acetoxynorbomane, A47.10 Norbomane-2-carboxylic acids, methyl esters, A47.10... 

The Diels-Alder reaction between oxazolone and cyclopentadiene in water was investigated by Cativiela (Eq. 12.35).96 Although the reaction is very slow, the ( )-5(4H)-oxazolone reacted with cyclopentadiene in an aqueous medium for six days at room temperature to form the corresponding sprioxazolones in a 95% yield. The cycloadducts were then readily converted into amino-norbomane carboxylic acids. 

In the late 1980s Frechet showed that high quality 13C NMR data of swollen gels could be readily obtained by MAS using a standard MAS probe (34-36). The first use of13 C MAS NMR data for combinatorial chemistry demonstrated that a potential reaction complication, the production of two similar compounds, could be monitored (37). The reaction of norbomane carboxylic acid... 

The occurrence of carbocationic intermediates in the Hofer-Moest variant of the Kolbe reaction can lead to numerous rearrangement processes. For example, electrolysis of carboxylic acid 68 in methanol results in the oxidative ring opening of the norbomane skeleton[30]. In a similar manner, GroB-type fragmentation of the decaline derivative 70 affords the 10-membered-ring ketone 71 in good yield (Scheme 12) [31]. 

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