Nonyl group

The idea for macrocydic peptidomimetic inhibitors of PDF originated from the structure of the reverse hydroxamate BB-3497 that was reported by Clements et al. [73]. On this basis, Hu et al. [81] designed the cyclic compound 135, in which a nonyl group serves as the cross-linked Pi and P3 side chain, as depicted in Fig. 8. 

The potassium channel, on the other hand, is blocked by both tetraethylammonium salts (7.3, TEA) and nonyl-triethylammonium (7.4) salts, indicating the presence of a hydrophobic binding site that accommodates the nonyl group. Both blocking agents must be applied intra-axonally, which is understandable if one considers that the K current is always directed outward. 

Fig. 17.70. Alternative II to the Wolff-Kishner reduction reduction of a tosylhydrazone. Due to the lack of a sufficiently strong base, the diazene intermediate D does not react further via a diazene anion, which was encountered in the reactions of the Figures 17.67-17.69, but undergoes a radical reaction. "Non" refers to a nonyl group.

Fig. 14.60. Alternative II to the Wolff-Kishner reduction reduction of a tosylhydrazone Non refers to a nonyl group.

Mandelate esters exhibit spasmolytic activity (they act as muscle relaxants). The nature of the alkyl group (R) greatly affects potency. Research indicates that the optimal potency is achieved when R is a nine-carbon chain (a nonyl group). Explain why nonyl mandelate is more potent than either octyl mandelate or decyl mandelate. 

Tris(nonylphenyl)phosphate (TNPP) is a common commercial phosphite. Note that this is not n-nonyl, hut rather a mixture of branched C9 isomers. Nonylphenol is commercially synthesized through Friedel-Crafts alkylation of phenol with nonene. Technical nonene ( propylene trimer ) is a mixture of predominantly C9-olefins with varying degrees of branching. The resulting nonylphenol is mainly a mixture of 4-substituted monoalkylphenols with various isomeric, branched nonyl groups [13]. Tris(2,4-di-t-butylphenyl)phosphite is another commonly used phosphite. 

Three-ring compounds bearing two lateral chains are often not liquid crystalline (e.g. [44, 46]), but corresponding four-ring mesogens, e.g. the oximesters 13 b with two laterally attached nonyl groups, can exhibit nematic phases with clearing points at about 140 °C [27]. 

The relevance of iV-trimethylsilyl-aminophosphines in several fields of chemistry led Wrackmeyer to develop the synthesis of the novel, fairly stable A/-trimethylsilyl-amino(dichloro)phosphine 8, in which the nitrogen atom bears a 9-borabicyclo[3.3.1]nonyl group (Scheme 2). 

Table 1 Effect of cation on the rate of nonyl group migration at 25 °C in THF...

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