Nonsuppressible insulin-like activity

Oelz, O., Jakob, A., and Froesch, E. R., Nonsuppressible insulin-like activity (NSILA) of human serum. Eur. J. Clin. Invest. I, 48-53 (1970). 

Zapf,., Schoenle, E., and Froesch, E. R., Insulin-like growth fuitors 1 and 11 Some biological actions and receptor binding characteristics of two purified constituents of nonsuppressible insulin-like activity of human serum. Ear. J. Biochem. 87, 285-296... 

Z4. Zapf, J., Kaufinann, U., Eigenmann, E. J., and Froesch, E. R., Determination of nonsuppressible insulin-like activity in human serum by a sensitive protein-binding assay. Clin. Chem. (Winston-Salem, N.C.) 23, 677-682 (1977). 

Froesch and collaborators (1963) demonstrated that most insulin-like activity in human serum was immunologically unlike insulin since only 5-10% of this activity could be suppressed by anti-insulin antibodies. This nonsuppressible insulin-like activity was purified from human serum (Humbel et ai, 1970) and was shown to consist of two polypeptides of molecular weight 7500 (Rinderknecht and Humbel, 1976). Because of their insulin-like effects in vivo and in vitro (Froesch et ai, 1975) these polypeptides were named insulin-like growth factors (IGF-I and IGF-II). 

Ginsberg, B. H., Kahn, C. R., Roth, J., Megyesi, K., and Baumann, G., 1979, Identification and high yield purification of insulin-like growth factors (nonsuppressible insulin-like activities and somatomedins) from human plasma by use of endogenous binding proteins, J. Clin. Endocrinol. Metab. 48 43. 

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