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Nonsteroidal anti-inflammatory drugs platelet effects

In two of the five spontaneous bleeding episodes described in Heading 4, medications that can affect platelet function or prothrombin time (PT) (i.e., aspirin and warfarin) were involved. Because GB is known to be an inhibitor of PAF (41), in theory GB could interact with antiplatelet drugs (e.g., aspirin, nonsteroidal anti-inflammatory drugs, clopidogrel, ticlopidine, dipyridamole) or anticoagulants (e.g., warfarin, heparin). EGb 761 was shown to potentiate the antiplatelet effect of ticlopidine in rats (42). However, in two studies in humans, the coadministration of GB with warfarin had no effect on either international normalized ratio or warfarin metabolism (43,44). [Pg.47]

Szczeklik, A, Musial J, Serwohska M (1975 b) The effect of aspirin on bleeding time and platelet aggregation in patients hypersensitivity to nonsteroidal anti-inflammatory drugs. Abstracts of the Xlth Congress of the Polish Society of Haematologists. Gdahsk, p64... [Pg.297]


See other pages where Nonsteroidal anti-inflammatory drugs platelet effects is mentioned: [Pg.151]    [Pg.134]    [Pg.135]    [Pg.12]    [Pg.199]    [Pg.481]    [Pg.450]    [Pg.772]    [Pg.910]    [Pg.1460]    [Pg.118]    [Pg.76]    [Pg.1166]    [Pg.249]    [Pg.74]    [Pg.416]    [Pg.1234]    [Pg.226]    [Pg.203]    [Pg.194]    [Pg.194]   
See also in sourсe #XX -- [ Pg.437 ]




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