Analgesic nonsteroidal anti-inflammatory drugs

Nonnarcotic Analgesics Nonsteroidal Anti-inflammatory Drugs (NSAIDs)... 

Chapter 18 Non narcotic Analgesics Nonsteroidal Anti-Inflammatory Drugs... 

Like aspirin, ibuprofen is a nonsteroidal anti-inflammatory drug. It is a cyclooxygenase inhibitor that interferes with COX-1 and COX-2 forms of that enzyme. Its effects on COX-2 give it fever-reducing (antipyretic), analgesic (pain relief), and anti-inflammatory functions. 

Nonsteroidal anti-inflammatory drugs (NSAIDs) may be initiated if acetaminophen therapy fails. At equipotent doses, all NSAIDs elicit similar analgesic and anti-inflammatory responses. Selection is based on patient preference, dosing frequency, tolerability, and cost. 

Simple analgesics such as acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) are first-line agents for treating OA (Table 55-2). 

NSAID—nonsteroidal anti-inflammatory drug (nonopioid analgesic) 02—oxygen P—phosphorus... 

Caffeine alone may produce analgesic effects in some forms of pain, but clinically it is most often used as an adjuvant medication (Laska et al. 1983 Ghelardini et al. 1997 Kraetsch et al. 1996 Forbes et al. 1991). It enhances the analgesic effects of nonsteroidal anti-inflammatory drugs such as acetaminophen and also speeds the onset of analgesia. It is effec-... 

NONSTEROID ANTI-INFLAMMATORY DRUGS AND ANTI-FEVER ANALGESICS... 

Nonsteroid Anti-Inflammatory Drugs and Anti-Fever Analgesics... 

Pharmacology Nonsteroidal anti-inflammatory drugs have analgesic, antipyretic, and anti-inflammatory activities. Major mechanism is believed to be inhibition of cyclooxygenase activity and prostaglandin synthesis. 

The combination of MAOIs with meperidine, and perhaps with other phenylpiperidine analgesics, also has been implicated in fatal reactions attributed to the serotonin syndrome. Aspirin, nonsteroidal anti-inflammatory drugs, and acetaminophen should be used for mild to moderate pain. Of the narcotic agents, codeine and morphine are safe in combination with MAOIs, although doses may need to be lower than usual. 

Chapter 36 Nonsteroidal Anti-Inflammatory Drugs, Disease-Modifying Antirheumatic Drugs, Nonopioid Analgesics, Drugs Used in Gout... 

Dozens of combination products are available only a few of the most commonly prescribed are listed here. Codeine combination products available in several strengths are usually denoted No. 2 (15 mg codeine), No. 3 (30 mg codeine), and No. 4 (60 mg codeine). Prescribers should be aware of the possible danger of renal and hepatic injury with acetaminophen, aspirin, and nonsteroidal anti-inflammatory drugs contained in these analgesic combinations. 

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