Nonsteroid receptor modulators

More experimental studies will be necessary to better understand the molecular basis of modulator effects both for the steroid receptor and nonsteroid receptor modulators. 

J.T. Dalton et al., US Patent 7,022,870 (April 4, 2006) Assignee University of Tennessee Research Foundation Utility Nonsteroidal Selective Androgen Receptor Modulators Useful for Treating Androgen-related Disorders... 

Phenyl benzofuran derivatives, (II), prepared by Miller (3), naphthalene derivatives, (III), prepared by Hamann (4), and 3,4-dihydro-3-aryl-hydroxybenzoxazines, (IV), prepared by Dickson (5) were effective as nonsteroidal androgen receptor modulators and used in the treatment of age-related disorders. 

Selective nonsteroidal androgen receptor modulators consisting of phenoxy, (IV), and anilino, (V), derivatives, were prepared by Dalton (3,4), respectively, and used in the treatment of androgen-dependent diseases including prostate cancer. 

Brown TR. Nonsteroidal selective androgen receptors modulators (SARMs) designer androgens with flexible structures provide clinical promise. Endocrinology 2004 145 5417-5419. 

Winneker RC, Fensome A, Wrobel JE, Zhang Z, Zhang P. Nonsteroidal progesterone receptor modulators structure activity relationships. Semin. Reprod. Med. 2005 23 46-57. 

Progesterone Receptor Overview of Modern Steroidal Progestins and Developments in the Field of Nonsteroidal Selective Progesterone Receptor Modulators... 

Winneker, R.C., Fensome, A., Wrobel, J.E., Zhang, Z. and Zhang, P. (2005) Nonsteroidal progesterone receptor modulators structure-activity relationships. Seminars in Reproductive Medicine, 23, 46-57. 

Nonsteroidal Tissue-selective Androgen Receptor Modulators... 

T. K. (1998) New nonsteroidal androgen receptor modulators based on 4-(trifluoromethyl) -2(1 H) -pyrrolidino[3,2-g] quinolinone. Bioorganic Medicinal Chemistry Letters, 8, 745-750. 

Mohler, M.L., Nair, V.A., Hwang, D.J., Rakov, I.M., Patil, R. and Miller, D.D. (2005) Nonsteroidal tissue selective androgen receptor modulators a promising class of clinical candidates. Expert Opinion on Therapeutic Patents, 15, 1565-1585. 

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