Nonspecific adhesion processes

Proteins such as antibodies and enzymes can be deliberately anchored on microfiuidic device surfaces by covalent bonds or molecular recognition in order to fabricate aiTay biosensors. Nonspecific adsorption is the (usually) undesirable adsorption of molecules on the surface, and it ends up with loss of analyte. In nonspecific adsorption, the molecule-surface interactions are initially weaker, so the adsorption process is both slower and more difficult to control. Subsequent denaturation leads to stronger adhesion [7], as well as to changes in the surface hydrophilicity and roughness [8]. It is important to understand the mech-... 

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