Nonsense-mediated mRNA decay

Abbreviations aa-tRNA Amino-acyl tRNA eLF Eukaryotic translation initiation factor IF Prokaryotic translation initiation factor eEF Eukaryotic translation elongation factor EF Prokaryotic translation elongation factor eRF Eukaryotic translation termination factor (release factor) RF Prokaryotic translation release factor RRF Ribosome recycling factor Rps Protein of the prokaryotic small ribosomal subunit Rpl Protein of the eukaryotic large ribosomal subunit S Protein of the prokaryotic small ribosomal subunit L Protein of the prokaryotic large ribosomal subunit PTC Peptidyl transferase center RNC Ribosome-nascent chain-mRNA complex ram Ribosomal ambiguity mutation RAC Ribosome-associated complex NMD Nonsense-mediated mRNA decay... [Pg.1]

The processes of nonsense-mediated mRNA decay and translational fidelity are intimately intertwined... [Pg.14]

Baker KE, Parker R (2004) Nonsense-mediated mRNA decay terminating erroneous gene expression. Curr Opin Cell Biol 16 293-299... [Pg.22]

Gonzalez Cl, Bhattacharya A, Wang W, Peltz SW (2001) Nonsense-mediated mRNA decay in Saccha-... [Pg.24]

Keeling KM, Lanier J, Du M, Salas-Marco J, Gao L, Kaenjak-Angeletti A, Bedwell DM (2004) Leaky termination at premature stop codons antagonizes nonsense-mediated mRNA decay in S. cerevisiae. RNA 10 691-703... [Pg.25]

Pdtz SW, Feng H, Welch E, Jacobson A Nonsense-mediated mRNA decay in yeasL Prog Nuddc Add Res Mol Biol 47 271-298,1994. [Pg.421]

Erick Noensie, Harry Dietz, A strategy for disease gene identification through nonsense-mediated mRNA decay inhibition. Nature Biotechnology, 19 (2001), 434 39. [Pg.298]

Lewis BP, Green RE, Brenner SE 2003 Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans. Proc Natl Acad Sci USA... [Pg.33]

Le Hir, H., Gatfield, D., Izaurralde, E., and Moore, M.J. (2001) The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay. EMBO., 20 (17), 4987 -4997. [Pg.334]

The main variation of EM that has been reported is cryo-electron microscopy (GEM). Of the reports on the use of GEM during this review period the most-studied structure is the ribosome (from various organisms) and its associated machinery. There have also been a number of studies on various viruses. Other studies that have been reported include ribonucleoproteins, the RNA guide surveillance complex from E.coli, a p53 tetramer bound to a DNA-encoding transcription factor response element, human RXR/VDR nuclear receptor in complex with its DR3 target DNA, a complex (UPF-EJG) from eukaryotic nonsense-mediated mRNA decay,and of a DNA origami structure. ... [Pg.196]

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