Nonreceptor protein tyrosine

Mode of Activation of Nonreceptor Protein Tyrosine Kinases.256... 

In spite of having no intrinsic catalytic domains, activation of T lymphocytes commences with tyrosine phosphorylations, activation of PLC-v with production of IP3 and DAG, and elevation of cytosolic free Ca2+. Thus, the consequences of receptor ligation are not dissimilar from those induced by the receptors for EGF or PDGF. An early study trying to explain the induction of tyrosine kinase activity resulted in the discovery of the nonreceptor protein tyrosine kinase Lck (p56lck), a T-cell-specific member of the Src family. Lck is associated with the cytosolic tail of CD4 (in helper T cells) or CD8 (in cytotoxic T cells) (Figure 8.14). As mentioned, the extracellular domains of these... 

Receptor Protein Nonreceptor Protein Tyrosine Serine/Th reonin SH2/SH3 Nucleotide Exchange ... 

Nonreceptor protein tyrosine kinases contain a catalytic domain, as well as various regulatory domains important for proper functioning of the enzyme 416... 

Nonreceptor protein tyrosine phosphatases are structurally different from serine-threonine phosphatases and contain a cysteine residue in their... 

Nonreceptor protein tyrosine kinases contain a catalytic domain, as well as various regulatory domains important for proper functioning of the enzyme. NRPTKs are found in the inner leaflet of the plasma membrane, cytosol, endosomal membranes and nucleus. These include the Src, Jak, Abl, Tec, Ack, Csk, Fak, Fes, Frk and Syk subfamilies (Fig. 24-3). Since a great deal is known about the structure and regulation of the Src family tyrosine kinase, we will use it to illustrate the principles in NRPTK signaling unique features in other subfamilies will be indicated... 

FIGURE 24-3 Nonreceptor protein tyrosine kinase (NRPTK) families. The family members are shown to the right and family name to the left of each NRPTK. Inset indicates the PTK catalytic domain and other domains for the regulation of localization and function. (From reference [5], with permission of Nature. Nature 2001.)... 

FIGURE 24-10 Schematic structures of nonreceptor protein tyrosine phosphatases (NRPTPs) and receptor protein tyrosine phosphatases (RPTPs). NRPTPs contain a catalytic domain and various regulatory domains. RPTPs are composed of an extracellular domain, a transmembrane domain and an intracellular domain with one or two catalytic domains. Like receptor protein tyrosine kinases, the structural features of the extracellular domains divide the RPTPs into different families. (With permission from reference [12]). 

NRPTK nonreceptor protein tyrosine kinase PMN progressive motor neuropathy... 

Taniguchi, T. Cytokine signaling through nonreceptor protein tyrosine kinases (1995) Science 268, 251-255... 

Elberg, G.,Z. He, J. Li, N. Sekar, andY. Shechter. 1997. Vanadate activates membranous nonreceptor protein tyrosine kinase in rat adipocytes. Diabetes 46 1684—1690. 

Pao LI, Badoiu- K, Siminovitch KA et al (2007) Nonreceptor protein-tyrosine phosphatases in immime cell signaling. Annu Rev Immunol 25 473-523... 

Sudol, M. Nonreceptor protein tyrosine kinases. Mol. Basis Hum. Cancer (Neel, B.G., Kumar, R., eds.) Futura, Mount Kisco, New York, 203-224 (1993)... 

Signaling pathways operated by nonreceptor proteins tyrosine kinase... 

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