Nonpeptide mimic

Kahn, M., and Devens, B., The design and synthesis of a nonpeptide mimic of an immunosuppressing peptide. Tetrahedron Lett., 27, 4841, 1986. 

R. Hershkoviz, N. Greenspoon, Y. A. Mekori, R. Hadari, R. Alon, G. Kapustina, and O. Lider, Clin. Exp. Immunol., 95,270 (1994). Inhibition of CD4-H T Lymphocyte Binding to Fibronectin and Immune-Cell Accumulation in Inflammatory Sites by Nonpeptide Mimics of Arg-Gly-Asp. 

C. Papageorgiou, R. Haltiner, C. Burns, and T. J. Petcher, Bioorg. Med. Chem. Lett., 2,135 (1992). Design, Synthesis, and Binding Affinity of a Nonpeptide Mimic of Somatostatin. 

Synthesis of funtionalized (Z)-fluoroalkene-type dipeptide isosteres (36) via Sml2-mediated reduction of y,y-difluoro-ot, -enoates 2.3.19. Reductive formation of fluoroolefins and subsequent conversion to diketopiperazine mimics (71). Nonpeptidic amide bond replacement... 

The potential utility of peptides as therapeutic agents with clinical applications is limited as a consequence of intrinsic peptide properties such as metabolic instability or poor transmembrane mobility. Hence, the design and synthesis of meta-bolically stable peptide analogs that can either mimic or block the bioactivity of natural peptides or enzymes is an important area of medicinal chemistry research. Numerous structural modifications to peptides have been examined in pursuit of molecules with more desirable properties [1-3]. These modified structures, peptidomimetics, are nonpeptide molecules that imitate the desired properties of the natural substances. 

Incorporation of i,2, 6 -Trimcthyltyrosine into Bioactive Peptides Used in De Novo Design of Peptidomimetics and Nonpeptide Agonist Peptide Mimics... 

Nonpeptidic scaffolds may also be used to position carbonyl groups for the nucleation of helices. In the present case, three successive carbonyl groups are positioned in 3,6-dimethyl-4-oxo-2,3,4,5,6,7-hexahydro-l//-indole-3,6-dicarboxylic acid (11) (Scheme 5) to mimic those in the first turn of an a-helix.112" Peptide H-Glu-Ala-Leu-Ala-Lys-Ala-NH2 was attached to 11 through a linking residue and helix induction was examined by CD and NMR. 

It is suggested that the bicyclic diastereoisomeric fr.mr-azetidine 519 is a convenient nonpeptidic framework which mimics the /3-turn topology of the Arg-Gly-Asp (RGD) tripeptide portion of the extracellular matrix protein, fibronectin, involved in cell adhesion <2003BML1561>. 

The initial study to suggest that nonpeptide opioid agonists also mimic IPC was reported by Schultz et al. [43] in the rat heart. These investigators found that exposure of the heart to three brief (5 min) infusions of morphine (100 pg /... 

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