Nonlymphoid tumors

AA protein is often deposited in chronic inflammatory diseases such as rheumatoid arthritis (incidence up to 20%) and other inflammatory joint diseases, and in chronic suppurative and granulomatous infections such as tuberculosis and osteomyelitis. Deposits of AA protein are also observed in nonlymphoid tumors such as renal and gastric carcinomas and in Hodgkin s disease. Deposits of AA protein are most often found in the kidneys, liver, and spleen, usually resulting in nephrotic syndrome and hepatosplenomegaly. 

Because IgM are the commonest paraproteins associated with carcinomata and other nonlymphoid tumors, this discussion has been reserved until here. The same remarks, however, apply to other paraproteins, IgG, etc., found with cancers. Five explanations are possible ... 

CD30, the most consistent marker of H/RSCs, is readily detected in formalin-fixed, paraffin-embedded tissues. " However, tumor cells in some nonlymphoid malignancies, including embryonic carcinoma, melanoma. 

Roake JA, Rao AS, Morris PJ, Larsen CP, Hankins DF, Austyn JM. Dendritic cell loss from nonlymphoid tissues after systemic administration of lipopolysaccharide, tumor necrosis factor, and interleukin 1. J Exp Med 1995 181 2237-2247. 

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