Nongenotoxic Mechanisms of Action

Peroxisome Proliferator-Activated Receptor Alpha (PPARa Agonists). A variety of chemicals including pharmaceuticals, pesticides, plasticizers, and natural materials produce an increase in pCTOxisomes in rodent liver following exposure (see Chapter 17) (Reddy and Chu 1996 Reddy et al. 1976). Based on the observation of peroxisome proliferation, the chemical and pharmaceutical 

TCACCT n TCACCT (PPRE PPAR Response Element) 

Importantly, many of these antioxidants are provided through dietary intake (Clarkson and Thompson 2000). 

TABLE 16.5. Reactive Oxygen Species Generation and Removal in the Celf 

Cellular antioxidants Enzymatic Catalase H2O2 02 + 2H2O 

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