Noncovalent interaction complementary

Self-assembly of complementary subunits via noncovalent interactions such as hydrogen bonding or metal-ligand interactions is an attractive approach for the... 

This dynamic process is commonly known as constitutional dynamic chemistry (CDC). While the concept of dynamic covalent chemistry defines systems in which the molecular (or supramolecular) reorganization proceeds via reversible covalent bond formation/breakage, dynamic systems based on noncovalent linkage exchanges define the concept of dynamic noncovalent chemistry. Dynamic combinatorial chemistry (DCC) can be defined as a direct application of CDC where libraries of complementary functional groups and/or complementary interactional groups interexchange via chemical (i.e., covalent) reactions or physical (i.e., noncovalent) interactions. 

The formation of the donor acceptor complexes of Figure 1 occurs by self-assembly , which is defined as the noncovalent interaction of two or more molecular subunits to form an aggregate whose novel structure and properties are determined by the natures and positioning of the components [27 32]. The construction of complex, multicomponent aggregates requires intermolecular interactions that are directional and/or selective. The selectivity, particularly in asymmetric and multiply-bonded systems, allows for considerable influence over the association process by careful use of complementary components. With directionality, it is possible to control the separation and, in some cases, the relative orientation between donor-acceptor subunits. 

The information that permits the self-assembly of biomolecules consists of the complementary shapes and distributions of charges and hydrophobic groups in the interacting molecules. Large numbers of weak interactions are required for supramolecular structures to form. In this diagrammatic illustration, several weak noncovalent interactions stabilize the binding of two molecules that possess complementary shapes. 

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