Nonapeptide libraries

One of the first studies, Dybwad et al. [193] used panning of a type 8 nonapeptide library, alternating positive selection on pooled sera from a number of rheumatoid arthritis (RA) patients, and negative selection (see reservations about the effectivity of such an approach, above) on sera from a control group. The experiment was moderately successful, in that the enriched phage population contained five unrelated clones which could... 

In comparison to a reporter peptide, the affinity of human TAP for a totally degenerate nonapeptide library was found to be 17-fold lower [20]. Single amino acid substitutions in the high-affinity reporter peptides resulted in only two- to three-fold differences in transport rates, but in up to 80-fold differences as revealed by the use of synthetic peptide libraries. 

Library 1.5 Nonapeptide Size 280 054 members Affiliation Selectide Corp. [7] Year 1995... 

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