Antagonism non-competitive

Figure 5. Scheaatic presentation o non-competitive antagonism using a double reciprocal plot.

The antimorphine action of Ca + has been reported to be both competitive and non-competitive. Our laboratory (34) Opmeer and Van Ree (32) and apparently Heimans (37) as well have reported a competitive-type antagonism. Later, we noted that with high concentrations of Ca- " a non-competitive antagonism occurred (36). 

Similar effects were stated to occur with rabbit synaptosomes, levorphanol causing a reduction of K -stimulated ->Ca uptake in vitro (65). Once again this was a stereospecific, naloxone-reversible and non-competitive antagonism. Also, chronic levorphanol treatment of mice produce increases in K+-stimulated uptake compared with controls. In this case no effects were seen with resting levels of Ca flux at 5 mM K+ (3). Very similar results were reported by End et al. 

For competitive dualism combined with non-competitive antagonism the term multiple antagonism is used the drug acts as weakly active agonist, competitive antagonist and non-competitive antagonist... 

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