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Competitive dualism

Fig. 10. Competitive dualism. Agonist A (a = 1 pi>2 = 7). Partial agonist B (P = 0-5 pD2 = P 2 = Both agonist concentrations (on the abscissa) and partial agonist concentrations (for each curve) are given as pi> values. Note the agonistic effects of the partial agonist B in the absence of the agonist A (Le. at pD j — where [A] = 0). Also note the parallel shift of the DRC as shown by the midpoints of the curves. For explanation see text. Fig. 10. Competitive dualism. Agonist A (a = 1 pi>2 = 7). Partial agonist B (P = 0-5 pD2 = P 2 = Both agonist concentrations (on the abscissa) and partial agonist concentrations (for each curve) are given as pi> values. Note the agonistic effects of the partial agonist B in the absence of the agonist A (Le. at pD j — where [A] = 0). Also note the parallel shift of the DRC as shown by the midpoints of the curves. For explanation see text.
For competitive dualism combined with non-competitive antagonism the term multiple antagonism is used the drug acts as weakly active agonist, competitive antagonist and non-competitive antagonist... [Pg.382]

Quantitative studies of ring-methylated phenylethanolamine derivatives led to precisely similar results (Misekova et dl., 1966) competitive dualism with autoinhibition in higher concentrations was found. [Pg.83]


See also in sourсe #XX -- [ Pg.381 ]




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