Nogo proteins

T cell specific to NoGo protein might induce neuroprotection in injured CNS... 

A third myelin inhibitory protein, OMgp, is a GPI-linked protein expressed by oligodendrocytes [18], OMgp is a relatively minor component of myelin, believed to be localized to the paranodal loops, next to the node of Ranvier. OMgp contains a leucine-rich repeat (LRR) domain and a C-terminal domain with serine/threonine repeats. Like MAG, OMgp is also found in the PNS. Like Nogo, OMgp is also expressed in adult neurons. 

MAPK mitogen-activated protein kinase NgR Nogo receptor... 

Why do neurons grow in the embryo but not in most parts of the adult CNS Two proteins called Nogo were isolated from bovine brain. Their sequences were utilized in identifying the Nogo gene and three human... 

GrandPre, T., Nakamura, F., Vartanian, T., and Strittmatter, S. M. (2000). Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. Nature 403, 439-444. 

Goldberg JL, Barres BA (2000) Nogo in nerve regeneration. Nature 403 369-370 Gow A, Sharma R (2003) The unfolded protein response in protein aggregating diseases. Neuromolecular Med 4 73-94... 

Nogo, named by Mardn Schwab of Zurich University, is a member of the endoplasmic redculum associated protein family, redculon. Despite being associated with endoplasmic redculum of oligodendrocytes, Nogo-A is also exhibited on the surface and mediates growth cone collapse (Fournier et al., 2002). 

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