NMDA receptors neocortex

Charpak S, Gahwiler BH, Do KQ, Knopfel T (1990) Potassiiun conductances in hippocampal neurons blocked by excitatory aminoacid transmitters. Natme 347 765-767 Chatterton JE, Awobuluyi M, Premkiunar LS, et al (2002) Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits. Nature 415 793-798 Chen HX, Roper SN (2004) Tonic activity of metabotropic glutamate receptors is involved in developmental modification of short-term plasticity in the neocortex. J Neurophysiol 92 838-844... 

A reduction of the total number of NMDA receptors in the neocortex has also been observed, presumably related to pyramidal cell loss (Francis et al. 1992). 

Regional distribution studies indicate that the highest density of kainate receptor occurs in the stratum lucidum of the hippocampus (mossy fiber system) and in the inner and outer layers of the neocortex. The highest density of NMDA receptors is found in the hippocampus, stratum radiatum, and in the striatum, thalamus, and cerebral cortex. The distribution of AMPA receptors is similar to that of NMDA receptors, but in the cerebellum AMPA receptors predominate in the molecular layer... 

Maura G, Marcoli M, Pepicelli O, Rosu C, Viola C, Raiteri M. Serotonin inhibition of the NMDA receptor/nitric oxide/cyclic GMP pathway in human neocortex slices involvement of 5-HT2c and 5-HT1A receptors. Br J Pharmacol 2000 130 1853-1858. 

Kumar SS, Huguenard JR. Pathway-specific differences in subunit composition of synaptic NMDA receptors on pyramidal neurons in neocortex. J Neurosci 2003 23(31) 10,074-10,083. 

Flint AC, Maisch US, Weishaupt JH, Kriegstein AR, Monyer H. 1997. NR2A subunit expression shortens NMDA receptor synaptic currents in developing neocortex. J. Neurosci. 17(7) 2469-76... 

Fig. 7. The distribution of the NMDA receptor NRl subunit mRNA splice variants in the adult rat brain (X-ray film autoradiographs, horizontal sections). Pan, NRl total mRNA AV, anteroventral thalamic nuclei Cb, cerebellum Cp, caudate putamen Cx, neocortex Dg, denate granule cells ER, entorhinal cortex Hi, hippocampus S, septum smc, sensori-motor cortex T, thalamus. Scale bar, 1.8. mm (Laurie and Seeburg, 1994). See Fig. 6 for explanation of the nomenclature.

AMPA, kainate and NMDA ionotropic glutamate receptor expression 6.3. NR3A EXPRESSION IN NEOCORTEX... 

Kharazia VN, Weinberg RJ (1997) Tangential synaptic distribution of NMDA and AMPA receptors in rat neocortex. Neurosci Lett 258 41-44. 

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