NMDA Antagonist Effects on Sensory Processing

NMDA antagonists reliably induce deficits in sensory gating measures, such as prepulse inhibition (PPI) that closely mimic the deficits seen in schizophrenia in both rodent (de Bruin et al., 1999  

Geyer et al., 2001) and primate (Linn et al., 2003) models. In contrast, ketamine appears to have little effect on either PPI or P50 gating in normal human volunteers ( Table 1.3-2). The basis for the dissociation between animal and human studies is unknown. However, these findings suggest that gating deficits in schizophrenia may reflect primarily nonglutamatergic pathology. 

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