Megaloblastic anemia nitrous oxide

There appear also to be toxic effects. In animals, nitrous oxide has been shown to inactivate methionine synthetase which prevents the conversion of deoxyuridine to thymidine and thus has the potential for inducing megaloblastic anemia, leukopenia, and teratogenicity (44—46). A variety of epidemiologic surveys suggest positive correlations between exposure to nitrous oxide and spontaneous abortion in dental assistants (47). 

Prolonged exposure to nitrous oxide decreases methionine synthase activity and theoretically can cause megaloblastic anemia, a potential occupational hazard for staff working in inadequately ventilated dental operating suites. 

B. Chronic nitrous oxide abuse may produce megaloblastic anemia, thrombocytopenia, leukopenia, peripheral neuropathy (especially posterior column findings), and myelopathy, similar to the effects of vitamin B,2 deficiency. 

Nitrous oxide (CAS 10024-97-2) A CNS depressant. Hematopoietic effects from chronic exposure include megaloblastic anemia. Substance abuse has resulted in neuropathies. May have an adverse effect on human fertility and fetal development. See also p 282. 50 ppm Coloriess gas. Sweet odor. Not combustible. Widely used as an anesthetic gas in dendstiy, and a popular dmg of abuse. 

---