Nitrosonium hexafluorophosphate Ritter reaction

Sodium superoxide in DMSO is a useful reagent for converting nitriles into amides. Isolated yields are above 70% for this reaction, which was unexpected as nitriles are inert to Na02 in other solvents. The mechanism is not completely understood. The Ritter-type synthesis of N-alkyl-amides from nitriles and alcohols can be improved by the addition of metal carbonyls to help stabilize the intermediate carbonium ions, and an alternative approach is to treat a nitrile with an alkyl halide and nitrosonium hexafluorophosphate. ... 

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See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ ]

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