Nitroso-methylurea

SUKUMAR, S., Notario, V., Martin-Zanca, D., AND Barbacid, M. (1983). Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations, Nature 306, 658. 

SYNS METHYLNITROSO-HARNSTOFF (GERMAN) N-METHYL-N-NITROSO-HARNSTOFF (GERMAN) METHYLNITROSOUREA 1-METHYL-l-NITROSO-UREA METHYLNITROSOUREE (FRENCH) MNU N-NITROSO-N-METHYLCARBAMIDE N-NITROSO-N-METHYI HARNSTOFF (GERMAN) NITROSO-METHYLUREA N-NITROSO-N-METHYLUREA 1-NITROSO-l-METFtYLUREA NMH NMU NSC-23909 Q RCRA WASTE NUMBER U177 SKI 24464 SRI 859... 

Gotoh T, Yamada K, Ito A et al. Chemoprevention of Y-nitroso-Y-methylurea-induced rat mammary cancer by miso and tamoxifen, alone and in combination. Jpn. J. Cancer Res. 89, 487 95, 1998. 

Yarita, T, Nettesheim, P. and Williams, M.L. (1978). Himor induction in the trachea of hamsters with N-nitroso-N-methylurea, Cancer Res. 38,1667. 

X-Nitroso-X-methylurea (see X-Methyl-X-nitrosourea) X-Nitroso-X-methylurethane (see X-Methyl-X-nitrosourethane) X-Nitrosomethylvinylamine... 

See individual entries for N-Nitrosodimethylamine, N-Nitroso-N-ethylurea, and N-Nitroso-N-methylurea. 

Wear protective gloves, laboratory coat, and goggles. Work in a fume hood. Add sufficient 3 M sulfuric acid (1.7 mL of concentrated sulfuric acid slowly added to 8.3 mL of cold water) to the waste to produce a solution not more than 5% in N-nitroso-N-methylurea. Add potassium perman-ganate to give a 0.3 M solution (0.5 g/10 mL). Stir the mixture at room temperature for 12 hours. Neutralize by cautiously adding 10% aqueous sodium hydroxide solution, then, while stirring, add a saturated aqueous solution of sodium bisulfite (approximately 10 g of sodium bisulfite per 35 mL of water), until a colorless liquid is formed. Wash into the drain with water.5,6... 

This is based on the reaction shown in Scheme 4.1. Diazomethane is prepared by decomposing N-nitroso-N-methylurea, N-nitroso-N-methyl-p-toluenesulphonamide or other substances with a similar configuration with a lye solution. An ethereal solution of diazomethane is added gradually to an ethereal solution of the sample until a permanent yellow colour is obtained [14]. To prepare diazomethane solutions, Fales et al. [15] used the apparatus shown in Fig. 4.1, available commercially in two sizes 1 mmol... 

SYNS NITROSO-l, 1-DIETHYL-3-METHYLUREA NITROSOMETHYLOIAETHYUIARNSTOFF NITROSOMETHYLDIETHYLUREA 1-NITROSO-l-METHYL-3,3-DIETHYLUREA... 

NITROSO-l-METPTYLUREA see MNA750 N-NITROSO-N-METHYLUREA see MNA750 NITROSOMETHYLURETHAN (GERMAN) see MMX250... 

Synonyms N-nitroso-N-methylurea 1-Methyl-l-nitrosourea MNU N-Nitroso-N-methylcarbamide Nitrosomethylurea N-Methyl-N-nitrosourea... 

N-Nitroso-N-methylurea was once widely used to synthesize diazomethane in the laboratory however, this use was replaced by other reagents. It has been studied as a chemotherapeutic agent in cancer treatment, either alone or in combination with... 

The potential for human exposure is limited because N-nitroso-N-methylurea is not produced or used in large quantities in the United States. 

The potential for direct exposure exists when injecting cancer patients with N-nitroso-N-methylurea in conjunction with cyclophosphamide, as a chemotherapeutic agent. Health professionals such as pharmacists, physicians, and nurses are potentially exposed to the compound during the preparation and administration of the pharmaceuticals or during clean-up. 

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