Nitrogen molecular model

The compound cyanoacetylene (HC=C—C=N) has been detected in interstellar space Make a molecular model or sketch the approximate geometry expected for this compound What IS the hybridization of nitrogen and each carbon" ... 

Draw or build a molecular model of what you would expect to the most stable conformation of the piperidine derivative In which the hydro- gen bonded to nitrogen has been replaced by methyl. ... 

A large number and diverse classes of compounds have been reported to possess tyrosinase inhibitory activities to various extents from the millimo-lar to nanomolar concentration ranges. From our laboratory we have also reported a large variety of tyrosinase inhibitors and for some of them we have performed molecular modeling as well. Among them there are several alkaloids, and nitrogen-containing molecules are also present. 

Khan MTH (2007) Recent Advances on the Sugar-Derived Heterocycles and Their Precursors as Inhibitors Against Glycogen Phosphorylases (GP). 9 33-52 Khan MTH (2007) Heterocyclic Compounds Against the Enzyme Tyrosinase Essential for Melanin Production Biochemical Features of Inhibition. 9 119-138 Khan MTH (2007) Molecular Modeling of the Biologically Active Alkaloids. 10 75-98 Khan MTH, Ather A (2007) Microbial Transformation of Nitrogenous Compoimds. 10 99-122... 

Part of the great efficiency of the intramolecular reactions of [26] and [27] is undoubtedly due to the correct alignment of the rigidly held nucleophile and carbonyl group. Molecular models show that in one of the conformations of [27] in which steric interactions are minimized, the phenoxide ion is immediately adjacent to the carbonyl group and in an excellent position for perpendicular attack (Bender, 1960) but other factors must also be important. Correct orientation would not explain why anionic nucleophiles are superior to neutral nucleophiles. Extensive studies have not been carried out with nitrogen nucleophiles in carbamate ester hydrolysis, but Hegarty and Frost (1972) found that carbamate [29] underwent elimination to an isocyanate. This can be contrasted with the... 

M. G. Voronkov u. VI. Knutov, Usp. Khimii 60, 2497-2527 (1991) engl. 1293 1308 . .Nitrogen- and Sulfur-containing Macroheterocycles and their Complexes. New Low-molecular Models of Enzymes". 

A quantitative estimation of the fraction of the 1,1 -cycles can be performed through a conformational analysis of the diepoxide molecules, i.e. determination of the number of their conformations in which the end-to-end distance is equal to the spacing between the nitrogen atoms in the corresponding diamine molecules. Such an analysis has given results qualitatively constistent with those obtained in the analysis of the molecular models by the Stewart-Brigleb method U0, n1,, I4>. 

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