2-Nitro-1-propanol

Methyl-2-Nitro-1-Propanol Nitrate (2-Nitro-2-methyl-l-propanol nitrate). 

The radiosynthesis starts with the nucleophilic F-fluorination of 2-benzyloxy-4-formyl-A/,A/,A/-trimethylanilinium trifluoromethanesulfonate or 5-benzyloxy-2-nitrobenzaldehyde. Subsequent condensation with nitroethane yielded the corresponding 2-nitro-1-propanol derivatives. Reduction of the nitro moiety and deprotection provided the four stereoisomers of " F-labeled 2-amino-1-(4-fluoro-3-hydroxyphenyl)-1-propanol and 2-amino-1-(2-fluoro-5-hydroxyphe-nyl)-1-propanol, respectively. 4-p F]FMR was isolated from the 2-amino-1-(4-fluoro-3-hydroxyphenyl)-1-propanol stereoisomer mixture via semipreparative HPLC and additional chiral HPLC for enantiomeric resolution. In a similar manner enantiomeric pure 6-p F]FMR was obtained. From a synthetic point of view, 4-p F]FMR appeared to be the more promising candidate for PET investigations due to higher radiochemical yields. The main advantage of the nucleophilic approach over the electrophilic methods is the obtained high specific radioactivity (56-106 GBq/pmol) that is desired for safe use in humans with tracer doses far beyond the pharmacological level [173]. 

C4H8N203 ethyl (aminocarbonyl)carbamate 626-36-8 25.00 1.2301 2 3732 C4H9N03 2-methyl-2-nitro-1 -propanol 76-39-1 22.50 1.0765 2... 

AI3-02258 EINECS 200-957-6 HSDB 5213 2-Methyl-2-nitropropanol 2-Methyl-2-nitropropan-1-ol 2-Methyl-2-nitro-1-propanol 2-Nitro-2-methyl-1-propanol 2-Nitro-2-methylpropanol NMP NMP Cone, NSC 17676 1-Propanol, 2-methyl-2-nltro-, Chemical and pharm-aceutioal intermediate, in tire cord adhesives, as formaldehyde release agents, deodorants, antimicrobials. Chemical intermediate, formaldehyde donor, textile reactant reduces formaldehyde on finished cloth. Solid mp = 89.5° bp ° = 94° Xm = 278 nm (MeOH) slightly soluble in H2O, soluble in organic solvents. Sigma-Aldrich Fine Chem. Whittaker dark Daniels. 

Nitro-1-propanol 1-Nitro-1-propene 2-Nitro-1-propene... 

Methyl-2-nitropropanol 2-Methyl-2-nitro-1-propanol. See 2-Nitro-2-methyl-1-propanol... 

CAS 76-39-1 EINECS/ELINCS 200-957-6 Synonyms 2-Methyl-2-nitropropanol 2-Methyl-2-nitro-1-propanol NMP Classification Nitro alcohol Empirical C4H9NO3 Formula CH3C(CH3)(N02)CH20H Properties Wh. crystals sol. in ethanol sparingly sol. in water m.w. 119.12 m.p. 90 C b.p. 95 C (10 mm)... 

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