Nitro compounds mutagenicity

Three examples concerning toxicity of heterogeneous data sets are given below. The first [50] relates to mutagenicity to Salmonella typhimurium of aromatic and heteroaromatic nitro-compounds ... 

The development of tandem MS techniques has undisputably contributed significantly to the basic understanding of fundamental aspects of nitro compounds. Further possible analytical applications have benefited from an advanced use of ion chemistry. In particular, the MS studies on nitroarenes (nitro-PAHs), which are known to be highly mutagenic, should be emphasized as fast and reliable analytical strategies. 

Chiu CW, Lee LFI, Wang CY, et al. 1978. Mutagenicity of some commercially available nitro compounds for Salmonella typhimurium. Mutat Res 58 11-22. 

Kawai A, Goto S, Matsumoto Y, et al. 1987. Mutagenicity of aliphatic and aromatic nitro compounds-industrial materials and related compounds. Japanese Journal of Industrial Health 29 34-54. 

De Leacy, E. A., Brown, N.N. Clague, A.E. (1989) Nitromethane interferes in assay of creatinine by the Jaffe reaction. Clin. Chem., 35, 1772-1774 Dellarco, VL. Prival, M.J. (1989) Mutagenicity of nitro compounds in Salmonella typhimurium in the presence of flavin mononucleotide in a preincubation assay. Environ, mol. Mutag., 13, 116-127... 

Debnath, A.K., Hansch, C. (1992) Structure-activity relationship of genotoxic polycyclic aromatic nitro compounds. Further evidence for the importance of hydrophobicity and molecular orbital energies in genetic toxicity. Environ. Mol. Mutagen. 20, 140-144. 

A.K. Debnath et al., Quantitative structure-activity relationship investigation of the role of hydrophobicity in regulating mutagenicity in the Ames test 2 Mutagenicity of aromatic and heteroaromatic nitro compounds in Salmonella typhimurium TA100. Environ. Mol. Mutagen. 19, 53-70 (1992)... 

A.K. Debnath et al., Structure-activity relationship of mutagenic aromatic and heteroaromatic nitro compounds. Correlation with molecular orbital energies and hydrophobicity. J. Med. Chem. 34, 786-797 (1991)... 

G. Caliendo et al., Shape-dependent effects in a series of aromatic nitro compounds acting as mutagenic agents on S. typhimurium TA98. SAR QSAR Environ. Res. 4, 21-27 (1995)... 

Dellarco VL, Prival MJ. 1989. Mutagenicity of nitro compounds in Salmonella typhimurium in the presence of flavin mononucleotide in a preincubation assay. Environ Mol Mutagen 13 116-127. 

Caliendo, G., Fattorusso, C., Greco, G., Novellino, E., Perissutti, E. and Santagada, V. (1995). Shape-Dependent Effects in a Series of Aromatic Nitro Compounds Acting as Mutagenic Agents on S. Typhimurium TA98. SAR QSAR Environ.Res., 4,21-27. 

Debnath, A.K., Compadre, R.L.L., Debnath, G., Shusterman, A.J. and Hansch, C. (1991). Structure-Activity Relationship of Mutagenic Aromatic and Heteroaromatic Nitro Compounds. Correlation with Molecular Qrbital Energies and Hydrophobicity. J.Med.Chem.,34, 787-797. 

Villemin, D., Cherqaoui, D. and Cense, J.-M. (1993). Neural Networks Studies. Quantitative Structure-Activity Relationship of Mutagenic Aromatic Nitro Compounds. LChim.Phys.Phys-Chim.Biol., 90,1505-1519. 

Villemin D, Cherqaoui D, Cense JM. Neural networks studies—Quantitative structure-activity relationship of mutagenic aromatic nitro compounds. J Chim Phys Phys Chim Biol 1993 90(7-8) 1505-19. 

The usual suspicion of carcinogenicity and mutagenicity that nitro compounds elicit have been documented with metronidazole in mice and rats. High-dose, long-term (lifetime) studies in these rodents have resulted in pulmonary, mammary, and hepatic tumor. 

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