Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Nitrile sulfides cyclizations

In a general annulation method, 4-aminonicotinonitriles are treated with ethyl orthoformate to give the corresponding (ethoxymethylene)amino compounds. The nitrile group is then converted with sodium hydrogen sulfide into a thioamide function which cyclizes to yield the 2-sulfanylpyrimidine moiety. An application of this method is the synthesis of 6-benzyl-5,6,7,8-tetrahydropyrido[4,3-t/]pyrimidine-2-thiol (3) from l-benzyl-4-[(ethoxymethylene)amino]-l,2,5,6-tetrahydropyridine-3-carbonitrile (2).491 492... [Pg.199]

See other pages where Nitrile sulfides cyclizations is mentioned: [Pg.1112]    [Pg.1165]    [Pg.1112]    [Pg.1165]    [Pg.384]    [Pg.283]    [Pg.157]    [Pg.141]    [Pg.927]    [Pg.316]    [Pg.356]    [Pg.927]    [Pg.100]    [Pg.30]    [Pg.21]    [Pg.81]    [Pg.683]    [Pg.1228]   
See also in sourсe #XX -- [ Pg.1165 ]

See also in sourсe #XX -- [ Pg.4 ]

See also in sourсe #XX -- [ Pg.4 ]



SEARCH



Cyclization nitrile

Nitrile sulfides

Sulfide, nitril

© 2024 chempedia.info