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Nitrile imines heterocyclic rings

As a class of compounds, nitriles have broad commercial utility that includes their use as solvents, feedstocks, pharmaceuticals, catalysts, and pesticides. The versatile reactivity of organonitnles arises both from the reactivity of the C=N bond, and from the abiHty of the cyano substituent to activate adjacent bonds, especially C—H bonds. Nitriles can be used to prepare amines, amides, amidines, carboxyHc acids and esters, aldehydes, ketones, large-ring cycHc ketones, imines, heterocycles, orthoesters, and other compounds. Some of the more common transformations involve hydrolysis or alcoholysis to produce amides, acids and esters, and hydrogenation to produce amines, which are intermediates for the production of polyurethanes and polyamides. An extensive review on hydrogenation of nitriles has been recendy pubHshed (10). [Pg.217]

Nitrile imines have been added to 1,4-diazepines (246) (143,144), 1,2, 4-triazepines (247) (145), 1-benzazepines (248) (146), 1,4-benzodiazepines (249-251) (147-149), 1,5-benzodiazepines (252, 253) (X = NH) (143,150-153), 1,5-benzothiazepines (253) (X=S) (153). Interest in this area has been stimulated by the known pharmacological activity of many compounds with five-membered heterocyclic rings fused to a benzodiazepine skeleton. [Pg.510]

Heterocyclic hydrazonyl halides which possess an amino-hydrogen undergo ring closure via 1,3-dipolar nitrile imines which can also be written as 1,5-dipolar ions. 1,5-Electro-cyclization then gives the fused product (Scheme 13). The method has been used for the preparation of 6,7-dihydro-3-aryl-5H-imidazo[2,l-c]-s-triazoles (72JCS(P2)1887),... [Pg.1008]

Other synthetic applications derive from various cyclizations that occur during reduction of the substrates that contain a reactive function at a specific position. These cyclizations proceed through the intermediate imine or amine to the cyclic amine. Various functional units such as olefins, heterocyclic rings, ketones, acids, amides, amines, nitrile, and nitro have been involved. Palladium, Rh, and finely divided Ni (Raney Ni) under more vigorous conditions are commonly used. Reductive cyclization of ketonitrile 1 over Raney Ni gives myosmine 2 along with some nomicotine 3 as overreduced product ... [Pg.294]

Dipolar cycloaddition of azomethine imine or nitrile imine-type dipoles with alkenes or alkynes yields nitrogen heterocycles containing two nitrogen atoms in the ring. MeOPEG resin was applied in the solid-phase synthesis of pyrazolines (Scheme 11.13). Resin-bound... [Pg.361]

Reaction kinetics for the interaction of 5-alkyliminothiatriazoles 52 or 58 with heterocumulenes, nitriles, ketones, imines, or other dipolarophiles a=b show that the decomposition of the thiatriazole is bimolecular, and new heterocyclic five-membered rings 71 are formed (Scheme 15). The term masked 1,3-dipolar cycloaddition was used by L abbe and co-workers for this type of reaction <1978JOC4951>, the thioimidate function being the masked 1,3-dipole. The reaction is thought to involve a thiapentalenic intermediate 70 with hypervalent sulfur. The product 71 is itself a masked dipole and often further reactions take place. [Pg.461]

Dehydrogenations, which involve the elimination of hydrogen Ifom organic molecules, lead to compounds containing double bonds, multiple bonds, or aromatic rings. For practical reasons, only the formation of carbon-carbon double bonds, of carbon-nitrogen double bonds in cyclic amines, and of aromatic rings (both carbocyclic and heterocyclic) will be discussed in this chapter. The conversion of alcohols into aldehydes and ketones and of amines into imines and nitriles will be discussed in the chapter Oxidations (Chapter 3). [Pg.47]


See other pages where Nitrile imines heterocyclic rings is mentioned: [Pg.213]    [Pg.94]    [Pg.541]    [Pg.94]    [Pg.37]    [Pg.252]    [Pg.396]    [Pg.397]    [Pg.758]    [Pg.758]    [Pg.74]    [Pg.93]    [Pg.85]    [Pg.758]    [Pg.22]    [Pg.526]    [Pg.1012]    [Pg.7]    [Pg.632]    [Pg.417]    [Pg.647]    [Pg.18]   
See also in sourсe #XX -- [ Pg.507 ]

See also in sourсe #XX -- [ Pg.507 ]




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Heterocyclic imines

Nitrile imine

Nitriles heterocycles

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