Nitric oxide superoxide reactions, chemistry

Barton DFIR (1996) On the mechanism of Gif reactions. Chem Soc Rev 25 237-239 Barton DFIR (1998) Gif chemistry the present situation. Tetrahedron 54 5805-5817 Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA (1990) Apparent hydroxyl radical production by peroxynitrite implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 87 1620-1624 Benson SW (1965) Bond energies. J Chem Educ 42 502-518... 

Pryor W. A. and Squadrito G. L. (1995). The chemistry of peroxynitrite a product from the reaction of nitric oxide with superoxide. Am. J. Physiol 268 L699-L722. 

We examine here a number of reaction pathways for nitric oxide, with the emphasis on assessing their biological relevance. To date, the fastest reaction for nitric oxide with clear toxicological significance is that with superoxide to produce ONOO" (Huie and Padmaja, 1993). Thus, the chemistry and reactivity of ONOO" are discussed at length. In addition, the interaction between ONOO" and nitric oxide is examined with respect to its effects on nitric oxide half-life as well as effects on peroxynitrite reactivity toward phenol. Reaction mechanisms are proposed to account for the nitrated, hydroxylated, and nitrosated phenolic products seen. 

The (bio)chemistry and physiology of superoxide and nitric oxide and their interactions with metal centers are very complex issues, which require a multidisciplinary approach. We are still not fully aware of the reactions that occur in relatively simple in vitro conditions and we know even less about the real processes on a molecular level imder the in vivo conditions. Systematic studies and reliable, comparable data on mnnber of different... 

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