Nitric oxide, fluorescent probes

Novel fluorescence probes for nitric oxide (DAMBO-P ) and for Zn " (ZnAB) have been developed based on BODIPY structure (Fig. 3). DAMBO-P is a pH-independent and more highly sensitive fluorescence probe for nitric oxide than DAF-2. ZnAB has the advantages of less sensitivity to solvent polarity and pH than ZnAF-2, fluorescein-based Zn " probe, and is also not influenced by other cations such as Na", K, Ca and Mg, which exist at high concentration under physiological conditions. 

Gabe Y, Urano Y, Kikuchi K, Kojima H, Nagano T. Highly sensitive fluorescence probes for nitric oxide based on boron dipyrromethene chromophore -rational design of potentially useful bioimaging fluorescence probe-. J Am Chem Soc 2004 126 3357-67. 

Lim MH, Lippard SJ (2007) Metal-based tum-on fluorescent probes for sensing nitric oxide. Acc Chem Res 40 41-51... 

Lim MH (2007) Preparation of a copper-based fluorescent probe for nitric oxide and its use in mammalian cultured cells. Nat Protoc 2 408-415... 

Lim MH, Xu D, Lippard SJ (2006) Visualization of nitric oxide in living cells by a copper-based fluorescent probe. Nat Chem Biol 2 375-380... 

Ouyang J, Hong H et al (2008) A novel fluorescent probe for the detection of nitric oxide in vitro and in vivo. Free Radic Biol Med 45 1426-1436... 

Plater, M. J. Greig, L Helfrich, M. H. Ralston, S. H. The synthesis and evaluation of o-phenylenediamine derivatives as fluorescent probes for nitric oxide detection. /. Chem. Soc., Perkin Trans. 1 2001, 2553-2559. 

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