Nitric Oxide and Vascular Disorders

The vasodilator and platelet-regulatory functions of endothelium are impaired during the course of vascular disorders induing atherosclerosis, the coronary artery disease, essential hypertension, diabetes mellitus and preeclampsia (DeBelder and Radomski, 1994), however the pathomechanism of these changes remains unclear. 

An impaired NO generation or action may also underlie the pathomechanism of vasospastic and finombotic changes of essential hypertension (Cadwgan and Benjamin, 1993 Calvcretal, 1992). 

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