Nitric oxide and the immune system

In view of the complexity of most physiological processes it is refreshing to note that a simple diatomic inorganic molecule has such a significant role in so much physiological chemistry. Of course, it is not without precedent dioxygen is also a simple, diatomic, inorganic molecule. 

Our grateful thanks go to many people who have assisted us in exploring this fascinating area on the borders of chemistry and physiology, but principally we thank Professor Salvador Moncada and his collaborators at The Wellcome Research Laboratories, England, who have been responsible for so much of what has been described. 

Spagnuolo, P. Rinelli, M. Coletta, E. Chiacone and F. Ascoli, Biochim. Biophys. Acta, mi, 911, 59. 

Springall, V. Riveros-Moreno, P. Chanez, P. Howarth, A. Redington, J. Bousquet, P. Godard, S. Holgate and J.M. Polak, Lancet, 1993,342,1510. 

Pepke-Zaba, T.W. Higenbottam, A.T. Dinh-Xuan, D. Stone and J. Wallwork, Lancet, 1991,338,1173. 

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