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Nitrenes amino

Iminoboianes have been suggested as intermediates in the formation of compounds derived from the pyrolysis of azidoboranes (77). The intermediate is presumed to be a boryl-substituted nitrene, RR BN, which then rearranges to the amino iminoborane, neither of which has been isolated (78). Another approach to the synthesis of amino iminoboranes involves the dehydrohalogenation of mono- and bis(amino)halobotanes as shown in equation 21. Bulky alkah-metal amides, MNR, have been utilized successfully as the strong base,, in such a reaction scheme. Use of hthium-/i /f-butyl(ttimethylsilyl)amide yields an amine, DH, which is relatively volatile (76,79). [Pg.264]

However, in some cases carboxylic acid-derived groups can participate in ring fission-reclosure reactions. Thus photolysis of 1,5-disubstituted tetrazole (399) gives nitrogen and appears to involve the amino-nitrene intermediate (400), which reacts further to give (401) (77AHC(21)323). [Pg.92]

Thiophene, 2-amino-3-cyano-5-phenyl-synthesis, 4, 888-889 Thiophene, 3-amino-4,5-dihydro-cycloaddition reactions, 4, 848 Thiophene, 2-amino-3-ethoxycarbonyl-ring opening, 4, 73 Thiophene, 2-amino-5-methyl-synthesis, 4, 73 Thiophene, 2-anilino-synthesis, 4, 923-924 Thiophene, aryl-synthesis, 4, 836, 914-916 Thiophene, 2-(arylamino)-3-nitro-synthesis, 4, 892 Thiophene, azido-nitrenes, 4, 818-820 reactions, 4, 818-820 thermal fragmentation, 4, 819-820 Thiophene, 3-azido-4-formyl-reactions... [Pg.890]

The procedure described is essentially that of Shioiri and Yamada. Diphenyl phosphorazidate is a useful and versatile reagent in organic synthesis. It has been used for racemlzatlon-free peptide syntheses, thiol ester synthesis, a modified Curtius reaction, an esterification of a-substituted carboxylic acld, formation of diketoplperazines, alkyl azide synthesis, phosphorylation of alcohols and amines,and polymerization of amino acids and peptides. - Furthermore, diphenyl phosphorazidate acts as a nitrene source and as a 1,3-dipole.An example in the ring contraction of cyclic ketones to form cycloalkanecarboxylic acids is presented in the next procedure, this volume. [Pg.188]

N-Aminobenzoxazolin-2-one (4), which was readily prepared by animation of benzoxazolin-2-one with hydroxylamine-O-sulfonic acid, is also a useful nitrene precursor (Scheme 2.2). Oxidation of 4 with lead(iv) acetate in the presence of a conjugated diene resulted in exclusive 1,2-addition of nitrene 5, to yield vinylazir-idine (6) in 71 % yield [6]. The formation of vinylaziridines through 1,2-additions of methoxycarbonylnitrene (2) or amino nitrene 5 contrasts with the claimed 1,4-ad-dition of nitrene itself to butadiene [7]. Since the reaction proceeded stereospecif-ically even at high dilution, the nitrene 5 appears to be generated in a resonance-stabilized singlet state, which is probably the ground state [8]. [Pg.39]

In many instances, however, the intermediate triazoline can be isolated and separately converted into the aziridine, often with poor stereoselectivity. The first practical modification to the original reaction conditions generated the (presumed) nitrenes by in situ oxidation of hydrazine derivatives. Thus, Atkinson and Rees prepared a range of N-amino aziridine derivatives by treatment of N-aminophthali-mides (and other N-aminoheterocydes) with alkenes in the presence of lead tetraacetate (Scheme 4.10) [7]. [Pg.121]

N,N-Dichlor-amine werden iiber die Nitrene zu Aminen, in Gegenwart von 1,4-Di-oxan zu 2-Amino-l,4-dioxanen umgesetzt2 ... [Pg.697]

Thermolysis of 5-amino-6-azido-1,3-dimethylxanthine 289 in chlorobenzene gave 3-aminoisofervenulin 290 possibly through a C-nitrene intermediate (92MI1). [Pg.244]

Thermolysis of 7-amino-6-azido-l,3-dimethylxanthine (386) in chlorobenzene gave 3-aminofervenulin (387) through a nitrene intermediate (92MI1). 7-Aminotheophylline 388 and 389 were oxidized by various oxidizing agents to give 309 and 311, respectively (89KGS95). [Pg.256]

A photoreactive nucleotide, 8-bromo-2 -deoxy-adenosine, was incorporated post-synthetically into a DNA sequence (35, Fig. 13) within the previously determined DNA contact site for the transcription factor. Upon irradiation the resulting nitrene cross-linked primarily to the 50-kDa subunit and covalently modified Lys-244. On the other hand, that amino acid residue appeared not... [Pg.204]

Fig. 5.8 Examples of polymers grafted from nanocarbons, (a) An ATRP initiator covalently attached to RGO via nitrene and carbodiimide chemistry was used for the growth of poly(2-(ethyl (phenyl)amino)ethyl-methacrylate). (b) A RAFT chain transfer agent is covalently attached to GO prior to polymerization of vinylcarbozole. Fig. 5.8 Examples of polymers grafted from nanocarbons, (a) An ATRP initiator covalently attached to RGO via nitrene and carbodiimide chemistry was used for the growth of poly(2-(ethyl (phenyl)amino)ethyl-methacrylate). (b) A RAFT chain transfer agent is covalently attached to GO prior to polymerization of vinylcarbozole.
FeCl2 has been used to catalyse nitrene transfer from l-butyloxycarbonyl azide to sulfoxides (to form sulfoximides), sulfides (to give sulfimides), and a ketene acetal (to form an a-amino ester). ... [Pg.270]

Trimethyl-2-azidobiphenyl thermolyzed in n-hexadecane gave only 4% 2,4,9-trimethylcarbazole, that is, the product of nitrene insertion into the ortho C-methyl bond the main products were 2 -amino-2,4,6-trimethyl-biphenyl and 250 (R = Me). An intramolecular dipolar cycloaddition com-... [Pg.168]

Substituted 3,5-dihydro-4//-pyridazino[4,5-, ]indol-4-ones 50 <2001H(55)1105, 2002T10137> and 2,5-dihydro-l/7-pyridazino[4,5-7]indol-l-ones 52 <2006T121> have been synthesized from 5-(2-aminophenyl)pyridazin-3(2/0-ones 49 and 4-(2-aminophenyl)pyridazin-3(27/)-ones 51, respectively. For this purpose diazotization of the amino groups was followed by a nucleophilic substitution with sodium azide affording aryl azides. Upon heating of these compounds, the ring-closed products were obtained most probably via the formation of an electrophilic nitrene (Scheme 10). [Pg.20]


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