Probenecid Nitrazepam

Probenecid reduces the clearance of adinazolam, lorazepam and nitrazepam. Increased effects (e.g. sedation) may be expected. Probenecid does not appear to interact with temazepam. 

Probenecid 500 mg daily for 7 days reduced the clearance of nitrazepam by 25% in healthy subjects. ... 

BrocloneyerNH, Merlins L, Klimek K, (joos M, C inhaus EE. Comparative effects of rifampin and/cr probenecid on the phannacokinetics of temazepam and nitrazepam. IntJ Clin Pharmacol Ther Toxicol (1990) 28,387-93. 

Probenecid inhibits the renal tubular clearance of many drugs and their metabolites, including some of the benzodiazepines. It also inhibits the glucuronidation of nitrazepam and lorazepam by the liver. The overall result is that these benzodiazepines accumulate and their effects are increased. Temazepam, which also undergoes glucuronidation, was not affected, possibly as increased sulfation compensated. ... 

Established interactions but of uncertain clinical importance. Be alert for increases in the effects (sedation, antegrade amnesia) of adinazolam, lorazepam and possibly nitrazepam. Reduee the dosage as necessary. Note that adinazolam is no longer available.There seems to be no direct information about other benzodiazepines, but those that are metabolised like lorazepam and nitrazepam (e.g. oxazepam) may also interact. Temazepam does not appear to interact with probenecid. 

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