Nilvadipine Rifampicin

Rifampicin markedly reduces the plasma levels of diltiazem, nifedipine, nilvadipine, verapamil and possibly reduces those of bamidipine, isradipine, lercanidipine, manidipine, nicardipine, nimodipine, and nisoldipine. They may become therapeutically ineffective unless the dose of the calcium-channel blocker is raised. Rifapentine and rifabutin would also be expected to reduce the levels of the calcium-channel blockers. 

A study in 5 healthy normotensive subjects found that rifampicin 450 mg daily for 6 days reduced the peak plasma level and AUC of a single 4-mg dose of nilvadipine by about 20-fold and 30-fold, respectively. The hypotensive effect and reflex tachycardia associated with nilvadipine alone in these subjects was also abolished by rifampicin. ... 

The interactions between diltiazem, nifedipine, or verapamil and rifampicin are established and of clinical importance. There is some evidence that bamidipine, manidipine, nilvadipine, and nisoldipine interact with rifampicin and the manufacturers of a number of other calcium-chan-... 

Saima S, Furuie K, Yoshimoto H, Fukuda J, Hayashi T, EchizenH. The effects of rifampicin on the pharmacokinetics and pharmacodynamics of orally administered nilvadipine to healthy subjects. BrJ Clin Pharmacol (2002) 53, 203-6. 

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See also in sourсe #XX -- [ ]

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