Nifedipine modification

C Duverne, A Bouten, A Deslandes, J-F Westphal, J-H Trouvin, R Farinotti, C Carbon. Modification of cifixime bioavailability by nifedipine in humans involvement of the dipeptide carrier system. Antimicrob Agents Chemother 36 2462-2467, 1992. 

Napoli et al. [286] found that the nifedipine treatment of stroke-prone spontaneously hypertensive rats (SPSHR) suppressed the plasma and LDL oxidation and the formation of oxidation-specific epitopes and increased the survival of rats independently of blood pressure modification. Their results suggest that the protective effects of calcium blockers of dihydro-pyridine-type on cerebral ischemia and stroke may, at least in part, depend on their antioxidant activity. In vivo antioxidant effect of nilvadipine on LDL oxidation has been studied in hypertensive patients with high risk of atherosclerosis [287], It was found that there was a significant decrease in the level of LDL cholesterol oxidation in patients after nilvadipine treatment. 

Wang, Z., Ikegami, K., Hirayama, F., Uekama, K. Release characteristics of nifedipine from 2-hydroxypropyl-(3-cyclodextrin complex during storage and its modification of hybridizing polyvinylpyrrolidone K-30. Chem. Pharm. Bull. 1993, 41, 1822-1826. 

Duverne C, Bouten A, Deslandes A, Westi>hal J-F, Trouvin J-H, Farinotti R, Carbon C. Modification of cefixime bioavailability hy nifedipine in humans involvement oftiie dipeptide carrier system. Antimicrob Agents Chemo er (1992) 36, 2462-7. 

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