Nicotinic acid localization

Hexopar inositol nicotinate nicotinic acid, hexoprenaline [ban, inn] (hexoprenaline hydrochloride [jan]) is a P-ADRENOCEPTOR agonist selective for the P2-subtype that therapeutically can be used as a BRONCHODIIATOR in ANTIASTHMATIC treatment, hexoprenaline hydrochloride hexoprenaline. hexuronic acid ascorbic acid, hexylcaine [inn] (hexylcaine hydrochloride [usan]) is an ester series LOCAL ANAESTHETIC, used by topical application for the local relief of pain, hexylcaine hydrochloride hexylcaine. hexylresorcinol [usan] is a urinary ANTISEPTIC and an ANTHELMINTIC. It inhibits melanosis (blackspot) in shrimps, and is used as a food additive for prevention of enzymic browning in shrimps and fruits, hexyltheobromine pentifylline. 

It thus appeared that the action of pyridine-3-sulfonie acid was localized at a reaction converting nicotinic acid to its amide, or at a similar stage of amide formation in a higher derivative. From this point of view, the action of cozymase as an antagonist to pyridine-3-sulfonic acid was unexpected, for the compound was less effective as antagonist than either the acid or amide but analogous phenomena have been discussed on page 417. 

Nonimmunologic contact urticaria (NICU) occurs in individuals not sensitized to the contactant, i.e., almost any normal subject. The mechanism of action is the result of a direct release of vasoactive substances, which causes a localized response [20]. Prostaglandins are mediators in the reaction to at least benzoic and sorbic acids and to methyl nicotinate, and systemic or topical inhibitors of prostaglandin synthesis inhibit the reaction to these substances [21-23]. Ultraviolet radiation (UVB and UVA) has also been shown to inhibit NICU reactions to some substances [24]. The NICU reaction is often redness without edema rather than a real wheal-and-flare reaction. The appearance of clinical signs depends mainly on the duration of exposure, the concentration of the contactant and other factors, such as rubbing or scratching. The reaction usually remains localized and systemic reactions are probably... 

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