Nicotine smoke

The mephenytoin metabolic pathway is utilized by commonly used drugs, such as mephobarbital, hexobarbital, diazepam, imipramine and omepra-zol, but only 3-5% of Caucasians and 8% of Blacks are poor metabolizers of mephenytoin, compared to 15-20% of Chinese and Japanese populations (Kupfer et al., 1988). This enzyme s activity is inhibited by floconazole and fluoxetine and induced by drugs such as barbiturates and nicotine (smoking). 

Hoffmann, D. Nicotine, a tobacco-specific precursor for carcinogens in Nicotine, smoking, and the low-tar programme, edited by N. Wald and P. Froggatt. Oxford University Press, New York, NY (1989) 24-40. 

Hoffmann, D. and 1. Hoffmann Significance of exposure to sidestream tobacco smoke in Environmental carcinogens. Method of analysis and exposure measurement. Vol. 9. Passive smoking, edited by l.K. O Neill, K.D. Brunnemann, B. Dodet, and D. Hoffmann, lARC, Lyon, France, lARC Sci. Publ. No. 81 (1987) 8-10. Hoffmann, D. and 1. Hoffmann On the reduction of nicotine in cigarette smoke in Nicotine, smoking, and the low-tar programme, edited by N. Wald and P. Froggatt, Oxford University Press, New York, NY (1988) 200-211. 

Schievelbein, H. and E. Werle Nikotin, Rauchen, und Organismus [Nicotine, smoking and organism] Beitr. 

MIPS targeting single high-priority analytes may also find broad usage and the role of the template here is to create a site capable of accommodating only one compound thus, it can exhibit a closer structural resemblance to the target. For instance, the nitrosylated nicotine metabolite 4-(methylnitrosamino)-l-(3-pyridyl)-l-butanol (NNAL) (4), a biomarker for nicotine smoke exposure, could be selectively retained by an MIP prepared using the isosteric enamine (5) as template. " ... 

Tobacco Nicotiana spp Nicotine Smoke as tobacco Strong stimulant... 

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