Nicotine hypertension with

Historically ganglionic nAChR have been targets for treating hypertension. The discovery of a large family of nAChR subtypes in the CNS, coupled with observations that nicotine has anti-nociceptive, neuro-protective and cognitive effects, has led to the recognition that neuronal nAChR are potential targets... 

Cardiac effects Hypertension, in some cases severe, requiring acute treatment, has been reported in patients receiving bupropion alone and in combination with nicotine replacement therapy. Exercise care if bupropion is used in in patients with a recent history of Ml or unstable heart disease. 

Accelerated hypertension - Nicotine therapy constitutes a risk factor for development of malignant hypertension in patients with accelerated hypertension. Inhaler therapy should be used with caution in these patients and only when the benefits of including nicotine replacement in a smoking cessation program outweigh the risks. 

Lobeline has peripheral effects similar to those of nicotine, whereas its central activity may be different. It has been associated with nausea, vomiting, headache, tremors, and dizziness. Symptoms caused by overdosage include profuse sweating, paresis, tachycardia, hypertension, Cheyne-Stokes respiration, hypothermia, coma, and death. Large doses are convulsant. 

Fregly, M. J., Lockley, O. E., Torres, J. L., and Cade, J. R., Effect of chronic dietary treatment with nicotinic acid on the development and maintenance of deoxycorticosterone-acetate-salt-induced hypertension, Pharmacology, 37, 50, 1988. 

It has been observed that the incidence of treatment-emergent hypertension is elevated among patients treated concurrently with bupropion and nicotine patches compared with patients treated with bupropion alone. 

Bupropion appears to reduce nicotine withdrawal symptoms and may simulate the actions of nicotine on the brain reward system. The most common side-effects related to bupropion are insomnia (30-45% at a dose of 300 mg/day) and dry mouth. Other commonly reported adverse events include hypertension, headache, and nausea. Seizures are a known risk associated with the use of somewhat higher doses compared with other antidepressants (0.1-0.4%), especially for the immediate-release form of the drug and when given at dosages of 450 mg/day or higher. Bupropion, unlike the TCAs, is virtually free of adverse cardiovascular effects, which makes it quite attractive for specific populations. 

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