Nickel-Induced Crystalline Inclusions in Mitochondria of the Ascending Limb

Nickel-Induced Crystalline Inclusions in Mitochondria of the Ascending Limb 

Nickel(II) exposure induced immortalisation of normal human kidney epithelial cells (Tveito et al. 1989). Growth inhibition by transforming growth factor Pi was abrogated in both the immortalised and transformed human kidney epithelial cells (Mollerup et al. 1996). 

It is noteworthy that other divalent metallic salts exert a similar effect on mitochondria of the basal infolding of epithelial cells of the distal nephron (Jasmin and Riopelle 1976). Piracetam that induced paracrystalline structures in the thyreocytes of old rats (Fig. 340) induced such an inclusion in a collecting duct epithelial mitochondrion (Fig. 315). 

Unilateral intrarenal injection of 2.5 or 5 mg Ni3S2 per rat induced marked glomerulomegaly and 

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