Stability niacinamide

Du J, Hoag W. The influence of excipients on the stability of the moisture sensitive drugs a.spirin and niacinamide comparison of tablets containing lactose monohydrate and tablets containing anhydrous lactose. Pharm Dev Technol 2001 6 159-66. 

Many vitamins are quite stable under normal processing conditions and present little or no stability problems in finished pharmaceutical products. These include biotin, niacin, niacinamide, pyridoxine, riboflavin, and a-tocopheryl acetate. Others that can present problems are ascorbic acid, calciferol, calcium pantothenate, cyanocobalamin, fola-cin, and retinyl esters. Overages above label claim are customarily added to vitamin formulations as a means of maintaining the claimed level of each vitamin for the expected shelf life of the products. The percent overage for a particular vitamin such as L-ascorbic acid will vary... 

Stabilization of vitamin B12 solutions in the presence of thiamine, niacinamide, and ascorbic acid has been the subject of a number of patents. Newmark (290) has described... 

Table 6.33 Equilibrium constants and calculated stabilization energies for niacinamide complexes...

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