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NHS Ester—Maleimide-Mediated Conjugation

In addition, the PEG-based heterobifunctional crosslinkers described in Chapter 18, Section 2, provide enhanced water-solubility for antibody conjugation applications. Conjugation of antibody molecules using a maleimide-PEG -NHS ester compound actually increases the solubility of the antibody and may help to maintain stability for certain sensitive monoclonals better than the traditional aliphatic crosslinkers. The methods described below for SMCC may be used with success for PEG-based reagents or other maleimide-NHS ester heterobifunctionals. [Pg.788]

NHS Ester-Maleimide Heterobifunctional Crosslinker-Mediated Hapten-Carrier Conjugation... [Pg.766]

Polymer linker can be used to conjugate nanoparticles to the surface of islets. One example is a heterofunctional PEG-mediated conjugation method by covalent-linkage [91]. The chemical conjugation was mediated by a heterobifunctional PEG polymer, maleimide-PEG-N-hydroxysuccinimide ester (NHS), which is biocompatible with blood, cell, and tissue. The maleimide group of the PEG polymer can react with the sulfhydryl group of the heparinized superparamagnetic... [Pg.31]

See other pages where NHS Ester—Maleimide-Mediated Conjugation is mentioned: [Pg.788]    [Pg.906]    [Pg.481]    [Pg.595]    [Pg.461]    [Pg.575]    [Pg.788]    [Pg.906]    [Pg.481]    [Pg.595]    [Pg.461]    [Pg.575]    [Pg.766]    [Pg.459]    [Pg.439]   


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Esters, conjugated

Maleimide conjugation

Maleimides

NHS Ester-Maleimide Heterobifunctional Crosslinker-Mediated Hapten-Carrier Conjugation

NHS Ester-Maleimide-Mediated Conjugation Protocols

NHS ester

NHS ester-maleimide

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