L-NG-monomethyl arginine

L-NMMA=NG-monomethyl-L-arginine L-NAME=NG-monomethyl-L-arginine LTP=long-term potentiation LTD=long-term depression. 

Weinberg JB, Granger DL, Pisetsky DS et al. The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease Increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine. J Exp Med 1994 179 651-60. 

Another important observation was that L-NG-monomethyl arginine (L-NMMA) could inhibit the formation of NO (Hibbs et al. 1987). This discovery of NOS inhibitors provided a novel tool to uncover the myriad of processes that NO is participating in, including damaging and protective mechanisms. While many speculated that NO may play the role of an enhancer in different pathophysiological processes due to its potentially toxic nature (Moncada et al. 1991), NO was also found to protect cells from oxidative stress and damage under ischemia reperfusion (Kubes et al. 1991 Ma et al. 1993 Wink et al. 1993). This dichotomous property of NO has been... 

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