Next-generation pharmaceutical impactor

Roberts DL, Romay FJ, Marple VA. Expected aerodynamic performance of commercial next generation pharmaceutical impactors. Presented at Respiratory Drug Delivery VIII, Tuscon, AZ, 2002. 

Kamiya A, Sakagami M, Hindle M, et al. Aerodynamic sizing of metered dose inhalers an evaluation of the Andersen and next generation pharmaceutical impactors and their USP methods. J Pharm Sci 2004 93 1828-1837. 

Marple VA, Olson BA, Santhanakrishnan K, et al. Next generation pharmaceutical impactor a new impactor for pharmaceutical inhaler testing. Part HI. Extension of archival calibration to 15 IVmin. J Aerosol Med 2004 17 335-343. 

Leung K, Louca E, Gray M, et al. Use of the next generation pharmaceutical impactor for particle size distribution measurements of live viral aerosol vaccines. J Aerosol Med 2005 18 414-426. 

Mitchell JP, Nagel MW, Wiersema KJ, et al. Aerodynamic particle size analysis of aerosols from pressurized metered-dose inhalers comparison of Andersen 8-stage cascade impactor, next generation pharmaceutical impactor, and model 3321 aerodynamic particle sizer aerosol spectrometer. AAPS PharmSciTech 2003 4 E54. 

Guo C, Gillespie SR, Kauffman J, et al. Comparison of delivery characteristics from a combination metered-dose inhaler using the Andersen cascade impactor and (he next generation pharmaceutical impactor. J Pharm Sci 2007 97(8) 3321-3334. 

The aerodynamic size distribution was analyzed using a Next-Generation Pharmaceutical Impactor (MSP Corporation, Shoreview, USA) in combination with a Copley Critical Flow Controller TPK and a Copley High-Capacity Pump HCP 5 (Copley Scientific Ltd., Colwick, Nottinghamshire, UK) [8],... 

The aerodynamic assessment of fine particles was performed according to the European Pharmacopeia method (2.9.18. preparations for inhalation aerodynamic assessment of fine particles, Ph. Eur. 8.0) [12] with the apparatus E, which is the Next Generation Pharmaceutical Impactor (NGl, Copley Scientific, Nottingham, UK). 

A significant effort occurred at the end of the 1990s to develop a new method of inertial sampling that had a greater application in pharmaceutical product development. This resulted in the manufacture of a the Next Generation Cascade Impactor. This device has the advantage of chambers that collect aerosol... 

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