Newman-Kuart rearrangement

The Chemical Development Drug Evaluation branch of Johnson Johnson Pharmaceutical Research Development LLC in Raritan, NJ, USA, tested microreactors for processes at elevated temperatures above the limit of most multipurpose conventional reactors, which is above 140°C 42j. Operation above this limit is possible only by means of special reactors equipped with heat transfer units. 

The Newman-Kuart rearrangement is an example of a high-temperature reaction [42]. Using a microreactor, the reaction temperature could be extended up to 200 °C. 0-(2-Nitrophenyl)-N,N-dimethylthiocarbamate was converted to S-(2-nitrophenylJ-N,N-dimethylcarbamothioate at 170°C in 14min in 90% yield. Quantitative 

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